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商品コード: 9783527333844

Transporters as Drug Targets

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分野別 > ライフサイエンス > 薬学

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書名

Transporters as Drug Targets
著者・編者 Ecker, G.F. et al.
出版社/発行元 Wiley-VCH
発行年/月 2017年2月   
装丁 Hardcover
ページ数/巻数 354 ページ
ISBN 978-3-527-33384-4
発送予定 海外倉庫よりお取り寄せ 2-3週間以内に発送します

 

Desciption

 

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.
Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation.
With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

 

Contents:

 

1 Insights into Transporter Classifications: an Outline of Transporters as Drug Targets
2 New Trends in Antidepressant Drug Research
3 The Molecular Basis of the Interaction Between Drugs and Neurotransmitter Transporters
4 γ-Aminobutyric Acid and Glycine Neurotransmitter Transporters
5 ABC Transporters: From Targets to Antitargets and Back
6 ABC Transporters Involved in Cholestasis
7 Recent Advances in Structural Modeling of ABC Transporters
8 PET Imaging of ABC Transporters at the Blood?Brain Barrier
9 The Systems Biology of Transporters ? Targeting the Regulatory System for Transporters (FXR/RXR)
10 ANO1 as a Novel Drug Target
11 Ligand Discovery for the Nutrient Transporters ASCT2 and LAT-1 from Homology Modeling and Virtual Screening
12 Organic Anion Transporting Polypeptides as Drug Targets

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