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商品コード: 9780128034736

The Zebrafish: Disease Models and Chemical Screens

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書名

The Zebrafish: Disease Models and Chemical Screens, 4th Edition, Volume 138
著者・編者 Detrich, H.W. III et al.
出版社/発行元 Academic Press
発行年/月 2017年1月   
装丁 Hardcover
ページ数/巻数 746 ページ
ISBN 978-0-12-803473-6
発送予定 海外倉庫よりお取り寄せ 2-3週間以内に発送します

 

Desciption

 

The Zebrafish: Disease Models and Chemical Screens, Fourth Edition, the latest volume in the Methods in Cell Biology series, looks at methods for analyzing genetics, genomics, and transcriptomics of zebrafish. Chapters cover such topics as gene-trap mutagenesis, genetic screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, developmental epigenetics, and the zebrafish interactome.

- Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies
- Includes chapters written by experts in the field
- Contains cutting-edge material on the topics discussed

 

Contents:

 

Part I: Adipose Tissue
Chapter 1. In vivo imaging and quantification of regional adiposity in zebrafish

Part II: Innate and Adaptive Immune Systems
Chapter 2. Innate immune cells and bacterial infection in zebrafish
Chapter 3. Best practices for germ-free derivation and gnotobiotic zebrafish husbandry
Chapter 4. Infectious disease models in zebrafish
Chapter 5. Live imaging the earliest host innate immune response to preneoplastic cells using a zebrafish inducible KalTA4-ERT2/UAS system
Chapter 6. Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells

Part III: Blood and Lymph
Chapter 7. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis
Chapter 8. Studying disorders of vertebrate iron and heme metabolism using zebrafish
Chapter 9. The lymphatic vasculature revisited?new developments in the zebrafish

Part IV: Visceral Organs
Chapter 10. Modeling intestinal disorders using zebrafish
Chapter 11. Analysis of pancreatic disease in zebrafish

Part V: Musculoskeletal System
Chapter 12. Using the zebrafish to understand tendon development and repair
Chapter 13. Small teleost fish provide new insights into human skeletal diseases
Chapter 14. Muscular dystrophy modeling in zebrafish

Part VI: Central and Sensory Nervous Systems
Chapter 15. Analysis of myelinated axon formation in zebrafish
Chapter 16. Zebrafish models of human eye and inner ear diseases

Part VII: Cancer
Chapter 17. A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response
Chapter 18. Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling
Chapter 19. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma
Chapter 20. Zebrafish models of leukemia
Chapter 21. Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain

Part VIII: Transplantation
Chapter 22. Transplantation in zebrafish

Part IX: Chemical Screening
Chapter 23. Chemical screening in zebrafish for novel biological and therapeutic discovery

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